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[2015 06 03] 정기세미나 12th

Multi-stimulus-responsive Nanovesicles for Biomedical Applications

MSE Graduate Students and Researchers

관리자 | 2015.06.02 12:01 | 조회 2623


Reception: MSE Graduate Students and Researchers

Reference: MSE Professors

Subject: The 12th Seminar - Spring Semester, 2015

 

 Date: 2015. 06. 03(WED), 17:00 ~ 18:15

 Place: Science Building, Room.202 Multimedia Room

 Title: Multi-stimulus-responsive Nanovesicles for Biomedical Applications

 Speaker: Prof. Sangyong Jon (KAIST)

Host of a Seminar: Prof. Sei Kwang Hahn

Speaker Language: ENGLISH

 

Abstract:

External or internal stimuli-responsive drug delivery systems have been of great interest in that drug molecules are to be released to the site of a disease in a controlled manner, thereby improving efficacy but minimizing toxicity. Here we report a dual light/ROS stimuli-responsive bilirubin nanovesicles (BNVs) for potential anticancer and anti-inflammation therapy. Bilirubin is a final metabolite of heme and functions as a potent antioxidant by scavenging ROS in our body. More interestingly, bilirubin can undergo photo-mediated isomerization to more water-soluble compounds. To use bilirubin for biomedical applications, it was first converted to pegylated bilirubin, which undergoes self-assembly to yield uniform nanovesicles with size of ~120 nm. In this lecture, preparation, characterization, and stimuli-induced disruption behavior of BNVs will be presented. Furthermore, as proof-of-concept, therapeutic efficacy of BNVs on a mouse colitis model will be also presented.

 


 

Department of Materials Science and Engineering


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