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[2018 05 11] 특별세미나 _Ph. D Haeshin Lee (KAIST)

Polydopamine Coating and TANNylation: Mussel and Plant-inspired Biomaterial Studies

관리자 | 2018.05.10 09:31 | 조회 682


Polydopamine Coating and TANNylation: Mussel and Plant-inspired Biomaterial Studies

 

 Date: 2018. 05. 11(Fri) , 14:00 ~ 16:00

 Place: Science Building, Room.202 Multimedia Room

 Speaker: Ph. D Haeshin Lee (KAIST)

Host of a Seminar: Prof. Sei Kwang Hahn

Abstract:

 

Catecholamines are found ubiquitously in nature. Wetting-resistant, adhesive foot-pads in mussels, neurotransmitters in the brain, melanin biopigments in the skin and eyes, squid beaks, and insect cuticles are the examples. In materials science, catecholamines have recently attracted significant attentions due to the unparalleled material-independent surface functionalization properties. The most well-known material is poly(dopamine) and other derivatives such as poly(norepinephrine), chitosan-catechol and others will be introduced.

 

The first of my talk will introduce a new concept of self-sealing which is similar yet different with conventional self-healing materials. The first example is vascular self-sealing with rapid binding of intrinsic blood serum proteins to adhesive chitosan-catechol conjugate (Shin et al. Nature Mater. 2017). The second example is plant-inspired nanoparticle formulation called TANNylation. In this study, we show that the modification of protein and peptide therapeutics with tannic acid—a flavonoid found in plants that adheres to extracellular matrices, elastins and collagens—improves their ability to specifically target heart tissue (Shin et al. Nature Biomed. Eng. 2018). Via a simple intravenous injection route, now one can easily delivery protein/peptide therapeutics directly to heart tissues. Finally, biomedical applications using polydopamine surface chemistry focusing on mammalian/stem cell culture and theranostic applications will be briefly explained in this talk.

 

Dept. of MSE / BK21+






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