세미나안내

[2018 04 30] 특별세미나 _Dr. Tony Z. Jia (Tokyo Institute of Technology)

Biopolymer self-assembly and combinatorial evolution processes at the origin of life

관리자 | 2018.04.27 09:25 | 조회 152


Biopolymer self-assembly and combinatorial evolution processes

at the origin of life

 

 Date: 2018. 04. 30(MON) , 18:30 ~ 20:00

 Place: Science Building, Room.202 Multimedia Room

 Speaker: Dr. Tony Z. Jia (Tokyo Institute of Technology)

Host of a Seminar: Prof. Seung Soo Oh

Abstract:

 

The emergence of life was governed by the ability for a system to develop

replication and metabolism; modern life uses biopolymers such as DNA and

proteins, respectively, for these purposes. Early life did not have access to large

amounts of these long biopolymers due to their energetically unfavorable

formation, but replication and metabolism are still necessary features of life. One

area of recent interest is the possibility of using supramolecular self-assemblies

and combinatorial evolution to assist in or catalyze these essential reactions.

These systems can be composed of simple small molecules or short oligomers

such as short peptides or nucleotides, all of which were readily available on the

early Earth (much more than longer biopolymers). The resulting structures,

whether they are nanofibers, hydrogels, crystalline structures, or phase-separated

compartments, potentially give rise to novel emergent properties that the smaller

individual components cannot. Here, we study the self-assembly, evolution, and

resulting structures of various prebiotically relevant supramolecular systems,

including short peptides, peptide/nucleic acid coacervate droplets, and

polyesters. We then probe the ability of these systems to perform prebiotically

relevant functions, including binding, compartmentalization, and catalysis.

 

Dept. of MSE / BK21+






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