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[2017 12 28] 특별세미나 _Ph.D. Ju Hun Lee (UC Berkeley, Bio-Nanomaterials Lab.)

Biomimetic M13 Bacteriophage based Self-assembly

관리자 | 2017.12.26 10:44 | 조회 131


Biomimetic M13 Bacteriophage based Self-assembly

 

 Date: 2017. 12. 28(Thu) , 16:00 ~ 18:00

 Place: Science Building, Room.202 Multimedia Room

 Speaker: Ph.D. Ju Hun Lee (UC Berkeley, Bio-Nanomaterials Lab.)

Host of a Seminar: Prof. Seung Soo Oh

Abstract:

 

1) Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720

2) Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720

 

Design of new materials with well-defined structures and desirable functions is a challenge in materials science, particularly when these materials have nanometer-scale dimensions.  In nature, however, complex functional nanostructures are created through the self-assembly of physically and chemically simple basic building blocks such as collagens, chitins, and celluloses during the development process. In this process, kinetic, thermodynamic, and environmental factors play a critical role in organizing helical nanofibers in a hierarchical structure. Through self-assembly process, the nanofibers self-organize into parallel, twisting, or rotating molecular orientations. In appropriate conditions, nanofibers can achieve momentarily favored far from equilibrium states that stabilize the nano- or micro-scale self-assembled structures that combine into macroscopically organized hierarchical structures. Such phenomenon of self-templated assembly and organization can also be recreated using organic and composite nanofiber materials. Recently, by mimicking self-assembly processes in nature, various functional nanomaterials have been developed using self-assembly of genetically and chemically engineered viral particles.

 

I firstly introduce chemically engineered M13 bacteriophage for templated assembly of nanoparticles in protein sensing applications. As an advanced approach for highly sensitive, reliable, simple, quantitative analysis of multiple markers in solution, we developed a nano-bio transducer based on chemically functionalizable M13 bacteriophage bio-recognition receptors as a template. Next, I focus on exploiting the helical nanofiber shape of M13 bacteriophage (phage) and its self-assembled liquid crystalline structures for designing helical-nanofiber-based diverse structures. As an example, we developed a novel sensitive and selective color sensor that utilizes cross-reactive M13 phage structural array matrices and an accompanying smartphone-based sensing system. Specifically, we developed tunable columnar smectic liquid crystalline phage color matrices using surfactant-assisted self-assembly process at the interface between liquid, solid, and air (meniscus) with genetically engineered M13 phage. Furthermore, after receptor functionalization by chemical and genetic engineering, phage color arrays show unique color changes that can be tuned by varying the bundle diameters and respond to relative humidity as well as various toxic volatile organic compounds such as benzene, toluene, xylene, and aniline. Through quantitative pattern analysis of color changes in phage colored array matrices, we were able to selectively identify the target chemical with single carbon difference and estimate its local concentration in a sensitive manner. We also implemented an automated real-time sensor analysis system to capture and share the sensing results through a smartphone-based wireless network. Lastly, I present my ongoing work about switchable depletion force induced double transition of elastin-like polypeptide (ELP) phage and ELP systems, and their helical hierarchical structure formation.

 

Dept. of MSE / BK21+






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