세미나안내

[2016 11 16] 정기세미나 8th

Nucleic Acid Biomaterials with Complex Functionalities

MSE Graduate Students and Researchers

관리자 | 2016.11.07 09:18 | 조회 767


 Date: 2016. 11. 16(WED) , 17:00 ~ 18:15

 Place: Science Building, Room.202 Multimedia Room

 Title: Nucleic Acid Biomaterials with Complex Functionalities

 Speaker: Prof. Seung Soo Oh (POSTECH)

Host of a Seminar: Prof. Jong-Lam Lee

 

Speaker Language: ENGLISH

 

Abstract:

 

Over the last few decades, nucleic acids (e.g., DNAs and RNAs) have proven to be an exceptionally versatile material beyond genetic information storage. As a sequence controlled polymer, they fold into a unique structure and create a variety of functionalities including molecular recognition, catalysis, construction of complex patterns, and even nanomechanical motions. Importantly, these synthetic constructs can be programmed to perform a wide range of molecular functions in a controlled manner—this is a powerful feature that cannot be easily realized in other macromolecules. Furthermore, when combined with other functional materials, they offer unique capabilities with regards to the creation of molecular machines that can perform complex functions in the right order at the right time.

To fully realize this potential, my work has focused on the development of novel methodologies to generate nucleic acid-based multi-functional biopolymers and their applications. Specifically, in this presentation, I will first introduce an innovative in vitro selection strategy enabling the discovery of functional DNA nanostructures that undergo binding-induced structure-switching. I will subsequently show that the generated synthetic allosteric regulators perform useful molecular functions for diagnostics, imaging and targeted therapy applications. Furthermore, I will demonstrate a unique catalytic RNAs (ribozymes) that recognize and polymerize the targeted short RNAs by processive ligation events. Finally, I will describe a novel synthetic method to create hybrid materials capable of performing complex, multi-step molecular processes by integrating targeting nucleic acids (aptamers) with other materials (e.g. engineered polymers) and demonstrate directly their applications in targeted drug delivery.

 

 

Department of Materials Science and Engineering

 


30POSTECH



205개(1/11페이지)
세미나안내
번호 제목 글쓴이 조회 날짜
205 [2018 05 30] 정기세미나 13th (박찬경 교수 정년퇴임 기념 첨부파일 관리자 151 2018.05.28 09:16
204 [2018 05 23] 정기세미나 12th 첨부파일 관리자 176 2018.05.21 09:11
203 [2018 05 16] 정기세미나 11th 첨부파일 관리자 210 2018.05.14 09:37
202 [2018 05 11] 특별세미나 _Ph. D Haeshin Lee (K 첨부파일 관리자 243 2018.05.10 09:31
201 [2018 05 09] 정기세미나 10th 첨부파일 관리자 157 2018.05.08 09:07
200 [2018 05 04] 특별세미나 _Dr. Hyobin Yoo (Harv 첨부파일 관리자 181 2018.05.03 09:48
199 [2018 05 02] 정기세미나 9th 첨부파일 관리자 145 2018.04.30 09:14
198 [2018 04 30] 특별세미나 _Dr. Tony Z. Jia (Tok 첨부파일 관리자 116 2018.04.27 09:25
197 [2018 04 25] 정기세미나 8th 첨부파일 관리자 136 2018.04.24 09:12
196 [2018 04 18] 정기세미나 7th 첨부파일 관리자 151 2018.04.16 10:44
195 [2018 04 09] 특별세미나 _Ph.D Seung Kwon Seol 첨부파일 관리자 202 2018.04.05 09:34
194 [2018 04 04] 정기세미나 6th 첨부파일 관리자 189 2018.04.02 09:02
193 [2018 03 28] 정기세미나 5th 첨부파일 관리자 229 2018.03.26 09:33
192 [2018 03 21] 정기세미나 4th 첨부파일 관리자 190 2018.03.19 09:34
191 [2018 03 20] 특별세미나 _Dr. Joon Sue Lee (UC 첨부파일 관리자 226 2018.03.16 10:52
190 [2018 03 14] 정기세미나 3rd 첨부파일 관리자 204 2018.03.12 09:14
189 [2018 03 07] 정기세미나 2nd 첨부파일 관리자 222 2018.03.06 15:43
188 [2018 02 28] 정기세미나 1st 첨부파일 관리자 250 2018.02.26 09:20
187 [2018 02 21] 신소재공학과 특별세미나 첨부파일 관리자 254 2018.02.19 11:15
186 [2018 02 02] 특별세미나 _Ph.D. Jang-Ung Park 첨부파일 관리자 412 2018.01.29 09:10