세미나안내

[2016 11 16] 정기세미나 8th

Nucleic Acid Biomaterials with Complex Functionalities

MSE Graduate Students and Researchers

관리자 | 2016.11.07 09:18 | 조회 326


 Date: 2016. 11. 16(WED) , 17:00 ~ 18:15

 Place: Science Building, Room.202 Multimedia Room

 Title: Nucleic Acid Biomaterials with Complex Functionalities

 Speaker: Prof. Seung Soo Oh (POSTECH)

Host of a Seminar: Prof. Jong-Lam Lee

 

Speaker Language: ENGLISH

 

Abstract:

 

Over the last few decades, nucleic acids (e.g., DNAs and RNAs) have proven to be an exceptionally versatile material beyond genetic information storage. As a sequence controlled polymer, they fold into a unique structure and create a variety of functionalities including molecular recognition, catalysis, construction of complex patterns, and even nanomechanical motions. Importantly, these synthetic constructs can be programmed to perform a wide range of molecular functions in a controlled manner—this is a powerful feature that cannot be easily realized in other macromolecules. Furthermore, when combined with other functional materials, they offer unique capabilities with regards to the creation of molecular machines that can perform complex functions in the right order at the right time.

To fully realize this potential, my work has focused on the development of novel methodologies to generate nucleic acid-based multi-functional biopolymers and their applications. Specifically, in this presentation, I will first introduce an innovative in vitro selection strategy enabling the discovery of functional DNA nanostructures that undergo binding-induced structure-switching. I will subsequently show that the generated synthetic allosteric regulators perform useful molecular functions for diagnostics, imaging and targeted therapy applications. Furthermore, I will demonstrate a unique catalytic RNAs (ribozymes) that recognize and polymerize the targeted short RNAs by processive ligation events. Finally, I will describe a novel synthetic method to create hybrid materials capable of performing complex, multi-step molecular processes by integrating targeting nucleic acids (aptamers) with other materials (e.g. engineered polymers) and demonstrate directly their applications in targeted drug delivery.

 

 

Department of Materials Science and Engineering

 


30POSTECH



153개(1/8페이지)
세미나안내
번호 제목 글쓴이 조회 날짜
153 [2017 03 29] 정기세미나 4th 첨부파일 관리자 138 2017.03.27 11:50
152 [2017 03 22] 정기세미나 3rd 첨부파일 관리자 1084 2017.03.20 09:28
151 [2017 03 15] 정기세미나 2nd 첨부파일 관리자 2268 2017.03.13 09:16
150 [2017 03 09] 특별세미나 Ph.D Rishi Raj 첨부파일 관리자 1449 2017.03.07 15:32
149 [2017 03 08] 정기세미나 1st 첨부파일 관리자 167 2017.03.07 09:13
148 [2017 02 22] 신소재공학과 특별세미나 첨부파일 관리자 164 2017.02.22 09:21
147 [2016 12 14] 정기세미나 12th 첨부파일 관리자 28936 2016.12.12 13:04
146 [2016 12 07] 정기세미나 11th 첨부파일 관리자 453 2016.12.05 09:11
145 [2016 11 30] 정기세미나 10th 첨부파일 관리자 520 2016.11.28 16:48
144 [2016 11 23] 정기세미나 9th 첨부파일 관리자 5625 2016.11.07 09:18
>> [2016 11 16] 정기세미나 8th 첨부파일 관리자 327 2016.11.07 09:18
142 [2016 11 15] 특별세미나 Ph.D Yadong Yin (Univ 첨부파일 관리자 268 2016.11.07 09:23
141 [2016 11 09] 정기세미나 7th 첨부파일 관리자 301 2016.11.07 09:18
140 [2016 11 02] 정기세미나 6th 첨부파일 관리자 313 2016.10.31 09:44
139 [2016 10 19] 정기세미나 5th 관리자 387 2016.10.17 15:32
138 [2016 10 12] 정기세미나 4th 첨부파일 관리자 296 2016.10.10 10:41
137 [2016 10 05] 정기세미나 3rd 첨부파일 관리자 382 2016.10.04 09:04
136 [2016 09 28] 정기세미나 2nd 첨부파일 관리자 476 2016.09.27 11:49
135 [2016 09 21] 정기세미나 1st 첨부파일 관리자 8651 2016.09.19 09:27
134 [2016 09 07] 신소재공학과 특별세미나 첨부파일 관리자 511 2016.09.05 14:15