세미나안내

[2016 11 16] 정기세미나 8th

Nucleic Acid Biomaterials with Complex Functionalities

MSE Graduate Students and Researchers

관리자 | 2016.11.07 09:18 | 조회 511


 Date: 2016. 11. 16(WED) , 17:00 ~ 18:15

 Place: Science Building, Room.202 Multimedia Room

 Title: Nucleic Acid Biomaterials with Complex Functionalities

 Speaker: Prof. Seung Soo Oh (POSTECH)

Host of a Seminar: Prof. Jong-Lam Lee

 

Speaker Language: ENGLISH

 

Abstract:

 

Over the last few decades, nucleic acids (e.g., DNAs and RNAs) have proven to be an exceptionally versatile material beyond genetic information storage. As a sequence controlled polymer, they fold into a unique structure and create a variety of functionalities including molecular recognition, catalysis, construction of complex patterns, and even nanomechanical motions. Importantly, these synthetic constructs can be programmed to perform a wide range of molecular functions in a controlled manner—this is a powerful feature that cannot be easily realized in other macromolecules. Furthermore, when combined with other functional materials, they offer unique capabilities with regards to the creation of molecular machines that can perform complex functions in the right order at the right time.

To fully realize this potential, my work has focused on the development of novel methodologies to generate nucleic acid-based multi-functional biopolymers and their applications. Specifically, in this presentation, I will first introduce an innovative in vitro selection strategy enabling the discovery of functional DNA nanostructures that undergo binding-induced structure-switching. I will subsequently show that the generated synthetic allosteric regulators perform useful molecular functions for diagnostics, imaging and targeted therapy applications. Furthermore, I will demonstrate a unique catalytic RNAs (ribozymes) that recognize and polymerize the targeted short RNAs by processive ligation events. Finally, I will describe a novel synthetic method to create hybrid materials capable of performing complex, multi-step molecular processes by integrating targeting nucleic acids (aptamers) with other materials (e.g. engineered polymers) and demonstrate directly their applications in targeted drug delivery.

 

 

Department of Materials Science and Engineering

 


30POSTECH



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