세미나안내

[2013 10 14] Special Seminar

Optical Contrast Agents: Tissue-Specific Targeting and Imaging

MSE Graduate Students and Researchers

관리자 | 2013.10.31 12:57 | 조회 2939


Reception: MSE Graduate Students and Researchers

Reference: MSE Professors

Subject: MSE Special Seminar_ Prof. Choi, Hak Soo (Change Place)

 

 Date: 2013. 10. 14 (Mon), 11:00 ~ 12:00

 Place: POSTECH BIOTECH CENTER, Room.182, Auditorium

 Title: Optical Contrast Agents: Tissue-Specific Targeting and Imaging

 Speaker: Prof. Choi, Hak Soo (Harvard Medical School)

Host of a Seminar: Prof. Sei Kwang Hahn

 

Abstract

Two fundamental and unsolved problems facing optical imaging are nonspecific uptake of intravenously administered contrast agents by normal tissues and organs, and incomplete elimination of unbound targeted agents from the body. To solve these problems, we have synthesized a series of indocyanine near-infrared (NIR) fluorophores that varied systematically in net charge, conformational shape, hydrophilicity/lipophilicity, and charge distribution. Using 3D molecular modeling and optical fluorescence imaging, we have defined the relationship among the key independent variables that dictate biodistribution and tissue-specific targeting such as lung and sentinel lymph nodes (Nat Biotechnol. 2010), human prostate cancers (Nat Nanotechnol. 2010), and human melanomas (Nat Biotechnol. 2013). Additionally, targeting on the endocrine glands could be achieved by mimicking natural hormone structures specific to the pituitary gland, thyroid gland, thymus, adrenal gland, and pancreas. Our study solves two fundamental problems associated with fluorescence image-guided surgery and lays the foundation for additional targeted agents with optimal optical and in vivo performance.

 

KEY WORDS: Nanotechnology; Optical imaging; Diagnostic imaging; Tumor targeting; Nearinfrared

fluorophore; Biodistribution; Clearance; Image-guided surgery

 

 

Department of Materials Science and Engineering



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